National stories are also often regional and local stories. I just pulled up the NYT website. The top story is the Derek Chauvin trial which is certainly also a local story in Minneapolis. The second from the top Opinion piece is about the NYC mayoral race. Does that mean that NYT shouldn't be able to accept any advertising dollars from those markets?
What is great about the regional model is the large number of regions which removes the need to not accept from a regiin. In your example Minneapolis is one of many cities the pressure local ad dollars never makes it's way to the editorial board.