There's no real long-term dependence. Going off the meds just returns me to my natural, dysfunctional self. I don't usually do that because it's disruptive without benefit.
The first type I tried happened to be right for me, so I didn't experience any negative effects. I did experiment with dose, though. Getting it right just feels like being more awake, which is how I describe the ability to choose where I hold my focus.
I think this varies highly from person to person. As someone who takes one to two days off a week, when possible, I must say I get some pretty brutal withdrawal side-effects.
None of the side-effects are really dangerous or life-threatening by any means, but they are still somewhat disabling. I've been taking my medication for about 8 years now, and I am starting to feel like the medication:
1. Has drastically diminished it positive returns
2. Is starting to take more away from me than it's giving back
Not sure, what other option I'll move to, but I do not have many of them left since I have tried almost all the various stimulant formulations multiple times minus Desoxyn.