I've tried Adobe Edge and the biggest issue I found was with the amount of HTML output and the human readability/context of elements. There seemed to be a lot of wrapper elements used in succession and named long, generic names with numbers. In my brief trial it looked OK in the browser but due to the excessive HTML, it would be a huge burden to edit in anything other than Adobe Edge if you wanted to go back and change anything. In a text editor, I can create a page using only 20% of the elements Edge did and have the opportunity to name them something relevant (e.g. #author_info rather than #generic-1-3-15).