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Quick guys someone make an MCP server with the codes. Fuck em!

The probability of COVID causing injury to your child is basically zero


Nanopore is good for hybrid sequencing. You can align the higher quality illumina reads against its longer contiguous reads

This is exactly why I'd rather get a fat VPS from a reputable provider. As long as the bandwidth is sufficient the only limitation is vertical scaling.


I'm partial to this, the only thing I've found that is harder to achieve is the "edge" part of cloud services. Having a server at each continent is enough for most needs but having users route to the closest one is not as clear to me.

I know about Anycast but not how to make it operational for dynamic web products (not like CDN static assets). Any tips on this?


Someone correct me if I’m wrong but:

DIY Anycast is probably beyond most people’s reach, as you need to deal with BGP directly.

One cool trick is using GeoDNS to route the same domain to a different IP depending on the location of the user, but there are some caveats of course due to caching and TTL.

EDIT: Back to Anycast, there are also some providers who allow you BGP configuration, like those: https://www.virtua.cloud/features/your-ip-space - https://us.ovhcloud.com/network/byoip - https://docs.hetzner.com/robot/colocation/pricing/ ... However you still need to get the IPs by yourself, by dealing with your Regional Registry (RIPE in my case, in Europe)


To get anycast working, you need BGP, and to get it working well, I think you need a good understanding of BGP and a lot of points of presence and well connected at each. BGP's default metric of distance is number of networks traversed, which does funny things.

Say you're in city A where you use transit provider 1 and city B where you use transit provider 2. If a user is in city B and their ISP is only connected to transit provider 1, BGP says deliver your traffic to city A, because then traffic doesn't leave transit provider 1 until it hits your network. So for every transit network you use, you really want to connect to it at all your PoPs, and you probably want to connect to as many transit networks as feasible. If you're already doing multihoming at many sites, it's something to consider; if not, it's probably a whole lot of headache.

GeoDNS as others suggested is a good option. Plenty of providers out there, it's not perfect, but it's alright.

Less so for web browsers, but you can also direct users to specific servers. Sample performance for each /24 and /48 and send users to the best server based on the statistics, use IP location as a fallback source of info. Etc. Not great for simple websites, more useful for things with interaction and to reduce the time it takes for tcp slow start (and similar) to reach the available bandwidth.


You could start using DNS Traffic Shaping where DNS server looks at IP making the request and returns the IP of closest server.

Azure/AWS/GCP all have solutions for this and does not require you to use their services. There are probably other DNS providers that can do it as well.

Cloudflare can also do this as well but it's probably more expensive than DNS.


Usury is wrong even if it should be obvious to the debtor


Society has to come down especially hard on usury specifically because the victim wants to do it.


Just drink the Koolaid. I hated the magic files but now I love them


Because those setups are too opinionated and mix too much stuff which makes them unstable. If you want a cohesive desktop experience, Mint Cinnamon is what you're looking for


Location: Anywhere, USA Remote: Sure Willing to relocate: Yes Hook: 3+ years of experience developing petabyte scale genomics ETL pipelines. Résumé/CV: https://www.linkedin.com/in/d-brod Email: me@danb.ro


Male instructors are more objective.


Source on this?

I've read that male instructors are expected to be more objective, and that female instructors are rated more poorly when they are more objective (https://gap.hks.harvard.edu/what%E2%80%99s-name-exposing-gen...) but not anything on the rates of objectivity itself


I wish the Cline extension was more performant. It has a 1000+ ms startup time for VScode and stutters occasionally. In terms of workflow though, it's my absolute favorite. I simply don't think the models are there yet for fully agentic coding in any reasonably complex/novel codebase. Cline lets me supervise the LLM step by step.


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