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Philosophy is the (surprisingly fertile) dowager empress of the sciences.

Physics may be the king, and Math the queen, but they always seem to be grinding their teeth and wishing that old biddy Philosophy would just finally die one day, and hand over the last her her powers, and she never really does.


It's like a layer between the sciences and the people these days. You almost certainly will always need something like that. Science can make discoveries but it doesn't amount to much until they get transposed to the human realm.


This is wonderful and I will steal it. Thank you :)


Maybe in BSL-5 labs?

Must be in rural isolation, NOT a city.

The administrators and janitors and everyone has to sleep inside the fence.

Getting out requires spending 40 days in a quarantine hotel in a different nearby fenced area.

Armed guards patrol the fence.

(EDIT: To be clear. BSL-5 doesn't exist yet... but it should.)


I agree. We should treat this as the existential threat that it is.


Maybe a fully underground, enclosed facility where scientists work and live. Oh, wait...


The lock down in the first Resident Evil movie seemed quite effective, until the response team reset the security system to get out.


Only to be defeated by a rubber gasket eating mutation.

Anyway Murphy's law is always applicable and we need the capability to fight fires even more.


> It is also much easier to stop bad software than bad biology. Software is much simpler than the human body.

As an RE geek, and a biologist, the Movies were so f'ing awful... I'm playing the new reboot of the Outbreak series, my favorite of all, RE: Resistance and its pretty awesome and still does way more with genre of survival horror in what was simply an add-on DLC cash-in to sell an updated RE3 then all the horrible movies combined. Online play was always more fun, but now that you're the villainous 'master mind' behind the plot kill the subjects for your own gain is absolutely brilliant, something sorely lacking the same Raccoon City Outbreak universe.

They simply did what Hollywood always does: make shit up and refused to speak about the Cyberpunk-esque undertones of Umbrella and the T virus in any adequate way. This works for comic book stuff because it's audience is so self-serving, but it's also why it's so boring and suffers from the repeated one dimensional story telling.

Instead of following the manga-style adaptions they have in Japanese cinema Hollywood made a series of mindless 2 hour brain drains of of zombie shooting banality, and then made up characters the main character (Jovovich) doesn't even exist in the lore, they deviated so far from the plot that they even managed to get Jill's character so bad I literately pissed of my date when we went I was nerd-raging so hard about how bad it was and how much a missed opportunity it was to inspire more like me to enter into biology--we were both freshman in University and I was at my peak of biopunk naivety and advocacy.

The animated series were way better, as is the case with Batman stuff and shows how gritty and dire these subjects are when properly told from the right platform and setting.

As for COVID, I witnessed how resurgance of the yellow movement in HK was being quelled by the CCP and PLA since that Summer, and I personally feel the theory that an accidental leaked gain of function virus makes sense but that nothing 'damning' will ever be uncovered as the floods that impacted Wuhan provided perfect cover to do any successful form of epidemiology, the wet markets are no longer a source of valid data and it was clear how the WHO who were refused at first from entering) is not to be trusted given their alliances to the CCP and refusal to acknowledge the efforts Taiwan had during this pandemic.

Sadly, political theater will always undo anything Science can prove (or not prove) even when it results in the death of 2+ million people. Let it not be forgotten the CCP was jailing, disspeaing and going fafter people on Social media for talking about the deadliness and serious nature of what was happening. Mainland Citizen-journalists who exposed the dire situation and the pathetic state of these make shift hospitals over run by are still not accounted for and are presumed to be either dissapeared in a black-site re-education camp, or simply murdered at this point.

That's why the CCP is such a threat, and its reliance needs to be broken from and decoupled: cheap labour and trinkets aren't worth having them be the vanguard for Human or even environmental health and denying and hiding, getting rid of any and all evidence when it suits them--which includes but is not limited to disspearing people and committing war crimes and acts of genocide while Xi speaks at DAVOS about creating a more 'diverse' system as it extinguishes ethnic groups it see's as threat to it's divisive death cult (CCP).


I may be wrong, but I think that by saying rubber gasket the parent commenter had "Andromeda strain" in mind.

I meant RE though


You’re not going to get any good researchers to live in a quarantine bubble for their whole lives.


Yes, just like no researcher will travel to Mars. /s


The point isn’t to live there their whole lives, but periods where they can get a lot of work done safely.


Then don't do it.


Do the good researchers themselves need to be near the viruses? Debt they just need some people to handle the work?


I scrolled to the bottom of the discussion, and have been scrolling up... THIS article is the best article on the subject I've read so far (including cited comparisons to other situations that are similar but slightly different) and I regret that I have but one upvote to give it.


I would argue that "the general public" paying a lot of attention to covid isn't THAT important.

The public's inattention on the topic of covid might almost be a blessing for key policy makers whose jurisdiction encompasses entire epidemiologically dense networks of people.

There are very few "epidemiologically coherent entities" in the western hemisphere that have the coordination capacity to solve covid, and "the ~328 million people in America" is not such an entity.

Sprawling metro areas (often crossing state boundaries) would need to form a new layer of government, that rivals many states, that covers entire physical metropolitan geographies, which we can't do quickly enough, so they might become green zones later in the process, if ever?

Rural counties? Perhaps small cities with urban growth boundaries AND a single municipal government? Incorporated towns with a single mayor. Possibly universities (depending on their capacity for epidemiological isolation)?

University re-opening committees of non-commuter-campuses MIGHT have the capacity and incentive to prevent their dorms from becoming plague zones. My current best hope is that some examples of this will arise in the next month or two at a small scale, and then (if we are lucky) they'll function as a templates for scaled up versions of the same thing in 2021.

Zeph Landau's guest post on Scott Aaronson's blog is the best US-college-centric policy document I know of regarding (1) the practical challenges around pooled screening, and (2) how to navigate these challenges.


The linked author doesn't seem to have a clear thesis statement, but from the examples given (the Hadza and the Conquistadors) it appears the thesis statement could be something like this: "Each isolated ancient human community already has basically optimized microbiomes. In each such human niche, their traditional microbes can probably survive in that niche. Also, those same microbes will have been surviving for so long that second order optimizations (like ethnic genetic adaptation to the potentially harmful parts of their traditional microbiome package) have likely occurred. In the face of such 'bio-traditions', and their presumptively functional state, we should tread carefully, and study everything before we muck about too much."

This seems to me like an excellent argument for why people who grew up on family farms, or in jungles, or other vaguely historical places should not muck about too much with their microbiomes. Heck, even third generation New Yorkers are probably solid.

However, it seems to miss the point that urbanization, immigration, antibiotic use, and radically weird diets (to name a few factors) are happening all over the modern world.

Given the modern situation, having already been disrupted by biologically unprecedented events for centuries, it seems plausible that at least some of us are like sailors at sea, with the metaphorical equivalent of scurvy-before-its-etiology-was-determined.

Just as, if you have scurvy, it doesn't cost much to try eating citrus and see if it helps, it seems that for people who are already unhappy with their gut health, it probably doesn't cost much to experiment here.

If you can already see that your digestion/mood/hunger is funky by comparing it do to friends and family, and you can read the research on that suggests these processes can be affected by microbiomes, it seems plausible to me that checking out uBiome or General Biotics or one of the "dating websites for poop" (or whatever, I'm sure there are more of these things floating around) it doesn't seem that crazy to me. A bit crazy, yes. But way less crazy than the same experimentation would be for someone who is eating and living in the same manner as their mother's mother, and has no more tummy troubles than any of their grandparents.

I've published a little in this area, and I didn't know about the conquistador story, so the article was appreciated, but I'm also personally a fan of experimentation that is early, fast, and cheap and I didn't see any of the experimental cost benefit analysis that could have been there, and could have made the article better.


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