i was just thinking how it always annoyed me that my garmin smartwatch doesnt have an off switch but that’s good context. though quartz doesnt have gps sensors..
On the contrary, this does not seem to be distinct with SARS-CoV-2. The other endemic coronaviruses (which cause pneumonia more rarely, and are typically just called 'common colds') also produce very similar 'long covid' effects in similarly tiny slices of the population.
Search your favorite repository of scientific literature for "{hku1|229e|oc43|nl63} cardiovascular" - you'll be amazed at how well documented, and yet poorly understood, this phenomenon is. There appears to be less literature for 229e, but pretty convincing for the other 3.
article itself mentions issue of hoarding glucose instead of using it. elevated HR via exercise basically forces glucose to be used so. not surprising at all.
ive seen those referenced more as the modern internet version of “the bar”. you pop in, engage in the current conversation in your desired channel, then good luck finding much in history.
That's over-simplifying by leaving out the "or more" part (which presumably exists because they only want to count full blocks). I do understand the gist of what they are saying but there's got to be a better way to word it.
I also wonder if theres a good statistical reason for only counting full blocks. Why not just stop at 30k?
Right, but you could use a fraction of the final block (using the known vote percentages for that block). Then it would be "a moving average of the last 30k votes" and not "a moving average of the last 30k or more votes".
do you have a write-up on how to make such a transition / do you have one or more that you read to learn about it? Mostly wondering about the nitty gritty like how to register as a business, tax considerations, simple contract stuff, etc. Seems to me that info is rarely in one place.
a better solution is raising minimum worker benefits & protections, pigovian taxes as well where necessary, etc. If a company cannot earn enough money while meeting some basic minimum requirements to society then it should fail quickly.
In the scenario you're asking for - the zombie companies just layoff employees, cut wages/benefits, landlords evict, etc. The zombie lives on just fine until the market corrects while everyone else fails.
You're correct that failing companies need to fail but your "just let the free market handle it" approach is a fairy tale.
So this seems to be the key paragraph about what starts the hardening.
>Using NMR spectroscopy, the researchers found that when the cells become stressed and die, they release PAR, which binds very strongly to calcium ions. Once released, the PAR starts mopping up calcium into larger droplets which stick onto the components in artery walls that give the artery its elasticity, where they form ordered crystals and solidify, hardening the arteries.
But then they don't discuss it at all - just talk about the potential solutions and discovery etc.
Can anyone elaborate on what this means "that when the cells become stressed and die"? Is this something we have control over? Is it related to stress? Does diet & exercise reduce the incidence of this? Is it inevitable?
Or from another angle "Once released, the PAR starts mopping up calcium into larger droplets which stick onto the components" does this imply that reduction of blood calcium (via exercise etc) reduces the impact of these cell deaths?
"Can anyone elaborate on what this means "that when the cells become stressed and die"? Is this something we have control over? Is it related to stress? Does diet & exercise reduce the incidence of this? Is it inevitable?"
I don't think you're going to find a straightforward answer because "cells becoming stressed and then dying" is typically a good and normal thing. Cells that refuse the cues to self destruct are roughly synonymous with "cancer cells".
When you undergo vigorous exercise, muscle cells (for instance) that cannot keep up with their energy demands undergo apoptosis and make way for other cells that have more efficient energy production. You can enforce natural selection of efficient mitochondria within your own body with vigorous, stressful exercise.
I encourage you to read the excellent book _Power, Sex, Suicide_ by Nick Lane which covers the topics of energy production in the cells and natural selection of mitochondria, etc. A fascinating book.
I would further encourage you to get as much vigorous exercise as you possibly can. There is no reason to pay any attention at all to trivial dietary and supplement optimizations if you aren't undertaking the intervention that covers the first 99% ...
Probably from oxidative stress which can be caused by psychological stress, poor diet, lack of exercise, social stress, smoking, irregular blood glucose, viruses and bacteria, etc. Pretty much the already known risk factors for heart disease.
But more importantly they die from normal processes required for life, so even without risk factors after living long enough everyone would get heart disease. Probably this is why they do not talk much about cells dying and talk about the ways to revert the effect of their death. Aubrey de Grey often talks about this when telling about the SENS foundation.
Do you speak any other languages / have you learned a 2nd language as an adult?
Pretty interesting how simply viewing the world through an ever so slightly different verbal lens can have interesting impacts on perspective. albeit mostly only little things. But as you alluded to, it's mostly only the little things that might catch you off guard anymore.
Yeah actually I should have added that. I speak two languages fluently (as in could do a literature degree, you wouldn't know I wasn't native if you heard me on the phone), another as mother tongue, another as 2nd mother tongue due to weird family history, and one from school. In addition lived in yet another language zone, and learning Mandarin as well.
Which is pretty interesting but I wish I had more time to explore it.
