Minuscule indeed. In the late 2000s I ordered a gram of desoxypipradrol [1] from a sketchy Chinese chemical company. A gram was the smallest unit they'd sell.
When it arrived we dissolved it in water at 1mg/mL so we could volumetrically measure 2mg doses accurately. Our first test doses were 500ug.
It took us so long to get though the jar that some mold started to grow on the solution, even though we kept it in the fridge! Not wanting to throw hundreds of doses down the drain we scooped off the mold, added Everclear (ethanol), redid our concentration math, and moved the jar to the freezer. Wild, innocent times.
Sadly, one of my friends in on the desoxypipradrol jar died from fentanyl contaminated dark web drugs a couple years ago.
Definitely a "take it in the morning and maybe skip the coffee" kind of thing. The effects feel like methylphenidate. I wish it was further explored commercially, but the duration is a very obvious reason not to.
”I've literally written RESTful Graph based data access APIs that don't do this. Multiple. At tech startups.”
Okay mr startup man, fact is you don’t know what you’re talking about and your head is so far up your startup ass you no longer know what’s good engineering.
Why are you writing your own restful graph based data access APIs?
Why do you mention GraphQL and JSON:API in the same sentence? The latter is at least 10x more difficult to understand with all its edge cases around entity relations and filtering.
And now it would be a political issue which drugs get manufactured for cheap and for whom. You can probably see how that would go in corrupted countries (i.e. all of them)
What’s weird is that people still think tobacco smoking is about nicotine being addictive and dangerous, when it is literally everything else in the smoke that makes it extremely addictive and mortally dangerous.
The nicotine is what makes it addictive, but everything else makes it deadly.
This distinction is well known here in Sweden where we have snus, and also lower rates of lung cancer and cigarette use than the rest of Europe by a LOT.
That is not true. It is the interaction of nicotine with various monoamine oxidase inhibitors that makes tobacco smoking addictive, to an extent that it could be stated that it is the MAOIs entirely causing the addictive behaviour: the exact same MAOIs are also found in coffee, after all.
Why are nicotine pouches and vapes addictive, then? The answer lies in the flavourings, which themselves have psychoactive properties, likely also through MAO inhibition.
I'm not here to argue, but all top 5 links for me are about smoking. I've not heard of people being addicted to nicotine patches for example, especially non-smokers.
I looked into this previously, though it was a while ago so I no longer have the sources to hand. Nicotine is still addictive on it's own but when given to non-smokers in a non-tobacco form it's notably less addictive than smoking. Still addictive but far closer to coffee than cigarettes.
Some of this can be explained by different consumptions methods. For example in lozenges, gum and patches nicotine enters the bloodstream much slower than smoking or vaping so even if you consume the same overall amount the peak is lower slowing adaption. But that couldn't explain it entirely.
You will have to supply something to back up such a wild statement. Nicotine has been shown to be extremely addictive all the way from humans down to single neurons in a petri dish, for decades.
It's not known in Australia where you have to have a prescription to buy a vape but can buy cigarettes freely. Apparently they're relaxing the prescription requirement later in the year but still only pharmacies will be allowed to sell them.
Going by a quick skim of the 2022 WHO oral health numbers, Sweden[0] doesn't seem significantly worse off oral-health wise than Germany, Holland, or the UK. In fact it's oral cancer incident rates appear a bit better. Though the UK doesn't have great cancer incident rates, it's periodontal disease rate seem to be significantly lesser than the other three (perhaps due to close monitoring as a result of the "bad British teeth" stereotype).
Sweden male tobacco use percentages are slightly higher than the other three countries, which might be a function of the population additionally using non-cigarette tobacco substitutes perhaps as was mentioned by others.
Not cancer. Because it's, again, not the nicotine that causes the cancer. Snus does NOT increase cancer risk.
It decreases cavities by a lot (presumably because the bacteria doesn't like the environment anymore), but also destroys your gums. All in all, depending on your dosage it could be a wash or even positive for your oral health.
It's absolutely disgusting, but it's not dangerous :P
