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I know right, dogs are really boring too, have you ever tried to engage one in conversation?


Depends on a dog, some beagles won't shut up if you speak with them.


I thought the name looked familiar. I'm not a doctor and I only googled for 10 minutes. I tore my achilles last year. I would never take this drug. I hope I'm off base.

Wiki breadcrumbs

https://en.wikipedia.org/wiki/Chloroquine

https://en.wikipedia.org/wiki/4-Aminoquinoline

https://en.wikipedia.org/wiki/Quinoline

https://en.wikipedia.org/wiki/Quinolone_antibiotic#Tendons


Chloroquine =/= quinolone class of antibiotics


Quinolone is some nasty (but effective) stuff. Chloroquine has a more benign side effect profile.


Reminds me of DFW

> the constant gnawing sense of having had and lost some infinite thing.


It's key to include false starts and promising paths that dead end. Learning to explore unknown solution spaces and refine the domain of the problem itself are critical skills in any open ended problem.

Spending an entire school lifetime being taught to "solve" "problems" and then being confronted with a world where problems aren't defined and solutions are ad-hoc and piecemeal is a rude awakening.

The strategies that made us a good students and made us feel good and smart in school aren't the same strategies that make for a good employee and those strategies set new devs up to fail when they can't "see the answer" to the current jira ticket they are tasked with.


It clearly did me in. It made me very sad that I could not write code to problems I have not seen before. I still haven't learned the mental skills necessary to face open problems with a curious mind. My first reaction to new problems is fear and anxiety to the extent I had to leave development entirely. I now do production support which is not what I intended to do. I wanted be a great developer.


Raise your hands, contribute to the spirit bomb.


I believe we are alone in Milky Way.

Self assembling replicators from some civilization should have colonized and cataloged every star system over billion year time scales.

It's inconceivable that no intelligent space faring civilization would have thought to do this.


Presuming we're not in a simulation then I think it is unlikely that we're alone in the Milky Way.

There are too many stars and too many close enough galaxies that could contain life. If they've been spacefaring for even ten thousand years longer than us then they're almost certainly able to monitor us without our ability to detect it.

But if we're doomed to a great filter in the near future, like nuclear war, then it still doesn't mean we're alone. It just means that out there in the sky there are others kinda like us. Searching for meaning before hitting a technological explosion of one kind or another that wipes us out. But just because we don't have contact doesn't mean we're alone, even if we're only present in each others respective imaginations.


It seems like you're assuming the difficult part about creating self-assembling replicators capable of sustained, error-free exponential growth across interstellar space and billions of years is merely coming up with the idea.

It's entirely conceivable that every space faring civilization which has tried has failed simply because the odds are so stacked against success, even once, at every step along that process. Just because the math is simple, doesn't mean the application is simple.

Hell, we don't even know what the odds are of becoming a space faring civilization to being with, and it doesn't seem axiomatic that every such civilization would even want to seed the galaxy with self-assembling replicators to begin with.


Maybe they did and it left no trace noticeable to us, or their policy is not to contact life-bearing planets, and did you read the article?


I've been mulling this over: given the constraints of information travelling at lightspeed and physical objects travelling at a lot less, what if it simply doesn't make financial sense for any actor in a market economy to colonize the galaxy?

What if the ROI of space colonization even at multi-decade or multi-century timescales is negative? Then why would anyone do it?


Market economy is far from a law of nature. Even most human activity is cannot be understood as market driven.


There doesn't have to be an economic motive

What if they just feel like exploring, and gaining knowledge, and seeing things no one else has ever seen?


Well, they'd still have to be able to pay for everything they need to go off on that voyage.


But what if that happens once every, say, 2 billion years on average? What is the likelihood we exist in a time close enough to that happening for us to be able to find ruins of it? That is the point the article made. There is an assumption that, if that happens, the colonization is permanent. Maybe that's not a good assumption.


Alien ruins would be nice to explore but oh well. If it really is like that, we can at least spread through it in a relative peace. :)


Maybe they're in the process of doing that but it just so happened that they haven't cataloged our system yet.


Plot-twist: We are those self-assembling replicators, and DNA/RNA is the deployment mechanism.


How much of the leading edge of astronomy is ground based, vs space based? Are they complementary or is space based going to eventually assume any and all roles ground based could?


That depends on the wave length regime.

Radio is firmly ground based, because you need huge dishes and potentially many (thousands) of them, at very precisely known distances.

IR is mostly space based (with SOFIA and ALMA the notable exception) because of atmospheric absorption.

Optical is firmly ground based, due to much lower cost for large telescopes. (See https://doi.org/10.1117/1.2031216 for the factors that affect cost). The notable exceptions are Hubble and satellites monitoring the sun such as Stereo and SDO.

X-Ray is space based again due to atmosphere.

Gamma-ray telescopes are an interesting mix between ground based air cherenkov telescopes (IACTs such as Hess, Magic and Veritas) and water cherenkov detektors such as HAWK and space based Fermi (with relatively poor sensitivity and low upper energy cut off, but very wide field of view).

Neutrino detectors are firmly ground based because the need huge detectors (the cubic kilometer of icecube is basically the lower limit).

So they are very much complementary. And some things will probably never moved to space, even if launch was free.


For radio telescopes, some Very Long Baseline Interferometry experiments have a space based component:

https://en.wikipedia.org/wiki/Very-long-baseline_interferome...



Slightly off topic but I love the fact that (over simplifying) some of our most advanced technology - for detecting neutrino - is a cubic km of ice.


It is very clean ice, with is shielded by another 1.5 km of ice on top and that is filled with more than 5000 photomultipliers.


If we are talking about visual light astronomy (the wavelengths where black satellites could help), a majority of astronomy is ground based. There exists just a single capable space observatory in visual light, the Hubble telescope, which will be going out of service in a few years. There's some metrics here[1] which show that about 10% of the most cited papers use Hubble data, which is still quite impressive. This is dated though, it could very well be that Hubble is becoming less relevant with recent advances in technology.

[1] http://www.stsci.edu/%7Ewebdocs/STScINewsletter/2003/spring_...


Electron hate is an entry in the genre, "modern software is inefficient and bloated because devs are lazy"

This genre will never want for new entries because, devs will keep getting things done and critics will keep complaining.

Electron hate is a moral argument, "devs are wasteful." It's not a technical argument. People confuse their ability to conceive of software which has the same behavior as shipped software, but improves on arbitrary figures of merit, excepting "date of RTM."


Modern software is inefficient because this is a cost-effective approach to building software. Wherever you can't pretend you have infinite resources, this attitude instantly evaporates. In other words, bloat matters to users, but not to whoever directs development (spoiler: that's rarely developers).


I dunno about best, but History of Rome podcast is excellent if you like podcasts as a format. Covers 750bc up to 450ad.

The coverage of punic wars, late republic, early empire, crisis of the third century are my favorite arcs.


How could it be the best comment when it doesn't even address OPs question?

OP asked for "X"

This reply says, "dont X, X is bad"

It is the same as every off topic top comment.


Your mileage may vary but the most helpful commentary I have gotten in my life is usually couched in that format: when I am asking for X, but had not considered Y enough, or at all, and someone replies suggesting Y instead, and then I realize new possibilities.


You are right that it does not answer OP's question. I stand by my words, it is still the best comment I have seen. Sometimes it is right to "dont X, X is bad", as it is an opinion which people may freely communicate. I will happily accept my text turning grey for expressing my opinions.


Reminds me of Stack Overflow.


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