I have MS and definitely didn't know that the secondary progressive form of the disease was just a matter of time. Now I'm slowly losing the right side of my body after years of being in remission with numbness in my hands being the only symptom.
There are definitely medical advances. The one I'm most excited about is nervgen. It's regenerative without the radiation and terribleness of stem cells. But it's only starting phase two trials.
Hang in there, it sucks but the doctors reassure me that it's a good time to have MS as thirty years ago there were no treatments.
Now there is the walking pill to help nerves conduct and it really works for me. There are also dmts that slow the progression or stop future lesions.
Stem cell therapy (autologous) involves wiping out your entire immune system and then rebuilding it from scratch using your own stem cells. It uses (usually) strong chemo drugs to do the wiping out, which themselves are toxic and have tons of side effects. You are rendered weak, with a high risk of secondary infection that requires you to basically isolate yourself until your immune system recovers. It’s very unpleasant. Close family member is currently in the midst of it for multiple myeloma, and spent an extra week in the hospital from secondary infection.
I will look into nervgen, initial search results say something about spinal cord neurons, is there anything for the brain?
Lastly, I'm not on a DMD, which one are you on, or would you recommend? I didn't understand they slow the brain atrophy part of the disease progress, do all or just some of them do?
Google says "(dalfampridine) Extended Release Tablets, 10 mg, is the first and only brand prescription medicine indicated to help improve walking in adults with multiple sclerosis (MS). This was demonstrated by an increase in walking speed."
Can confirm. It helps me out. It is a potassium channel blocker that somehow improves nerve conduction in the lower body. It has been available at compounding pharmacies for a very loving time. A company took that, made it a time release pill, went through the FDA hoops, and then released it as Ampyra. Like all MS drugs it was super expensive. Now the generic is available. Still expensive, the number I see is something like $1100 a month. My pharmacy told me they bill the insurance company $180 lol.
If you don’t have insurance or it doesn’t want to cover it, you can get a prescription and a compounding pharmacy can make it for you. If they don’t do time release you’ll have to dose every 3 hours or so. It’s a lot less expensive though. Last time I checked it was less than $100 a month.
I would like that to be not so but my understanding is that MS is a continuous process from the start, and that the relapsing/progressive distinction is mainly a factor of its effects relative to age.
I'm a CPA and I recommend my extremely small businesses clients use a single entry excel system. If they use debit for everything they can download the bank transactions in csv. Then use a deep downlist to categorize the transactions. Then a pivot table to display the year end or quarterly income statement. I usually send them the Excel with the pivot table and dropdown list.
Ahhhh, right, my best-loved “we are drowning and have no idea why, can you look at our 40 xls and few html tables” type of client.
Excel and single-entry in general allows one to ignore questions about their financial structure, make decisions that lead to massive analytic information losses and bury a relatively good business in a deep grave of multiple “idk” levels of knowledge. They only become aware of it when it stops scaling (but competition does, for some reason) or a market goes down for a while (but competition doesn’t care, for some reason). Digging them out is a hard and tearful task.
the problem with being a larger entity is there may be legal requirements around your accounting system.
In many EU countries, if your turnover (total amount of money flowing through your business) is over a certain amount, or if you are incorporated (rather than sole proprietor) you have a legal requirement for double-entry accounting, and in some places a legal requirement to have an external firm do your accounting.
Yes, but once you are using Power BI you have lost the friendly interface the op described for categorising transactions, ie it is not a simple spreadseet any more.
If you can charge your car both at work and at home that advantage is reduced drastically.
On the other hand you still think about those 0.1% of trips when you buy your car, which is why people have big cars for their family to handle holiday trips even if they are half empty 99% of the time. And you don't want to have to stop every 400km to charge your car when you go in holidays, especially if it means staying in a saturated station for 30 minutes.
I know you have to get some rest but many people just switch driver and only have a real break every 5 -6 hours, which means around 700km, and current EV don't have that range. In addition, you can take some rest wherever you want, for instance by a lake or in the forest, whereas if you need to charge your car you will be forced to be in an ugly fast charging station :(.
I still believe in EV though and I am convinced it will take over the market progressively, those are just temporary problem that explain why their market share is still so low, but it's improving.
How often are these long road trips though? Would you really not get an EV because very rare road trips take slightly longer, but meanwhile you're saving lots of money the whole year long on gas costs and not destroying the environment?
I can't imagine letting a few longer stops during infrequent long distance road trips being the deciding factor in what kind of car I'd buy.
Like many a middle aged dad, I have become afflicted with boating disease. One of the many problems that comes with owning a boat is that you need some way to tow it. Another problem is that you want your boat to be as easy to use as possible. If I had an electric car I would have to go to home depot and rent a truck every time I wanted to tow the boat. This is too much yak shaving.
In conclusion, my advice as a boat owner is: Never buy a boat.
The vast majority of people don't own a boat though ... and it's not like ICE sedans are any good at towing either.
Also, how sure are you that EVs are bad at towing? Don't they have lots of low-end torque? The Model X apparently has the highest towing capacity of any passenger vehicle. Beyond that you'd need a bigger truck anyway.
I think the future for urban dwellers is fast charging your EV while shopping. With large enough batteries it should only be necessary to charge the car once a week.
Also, most streets and parking lots in urban settings are already by law required to be electrified for minimum lighting requirements and/or parking meters. Extending the electrification requirements to include car charging seems only a matter of time. (Potentially especially in the cases where it makes sense to push for Smart Grids at the same regulative time.)
Some companies have already built interesting versions of street lamps and parking meters that double as car chargers (including at least one London company that was working to make sure that they could meet historic preservation standards of the street lamp design in London's core).
Road-embeddable induction chargers could even be an option soon in urban environments (particularly large parking lots for instance) where there isn't such existing "furniture" to take advantage of.
Maybe eventually there won't be an advantage... We might need the battery capacity to stabilise the power grid if we add more renewable sources like solar.
I actually made money off of an exclusive back in the GameCube day. They did The Legend of Zelda: Collector's Edition for the GameCube that had both games released for the NES and Nintendo 64, with the former including revised texts fixing the original mistranslations, a demo of The Wind Waker, and various promotional videos.
It was going for 50-100$ on eBay. The only way to get it was to get a subscription to Nintendo Power during the promotion so... yeah.... I was getting a few dozen Nintendo Power magazines in the mail every month for a year and pocketing 20-70$ per subscription after the sub price and eBay/PayPal fees.
Funny thing was, if people messaged me and just asked how I got the copies I flat out told them "just go get a Nintendo Power subscription".
I can't remember how I got a copy of the Collector's Edition, because I don't think I had an NP subscription. Was it a pre-order bonus for Wind Waker as well?
In any case, I found it endlessly amusing when I would go to Gamestop and see used copies of the Collector's Edition marked for sale at $50 or so. Particularly with the giant "NOT FOR RESALE" text on the cover:
>In the United Kingdom, the Collector's Edition was available to GameCube owners who mailed Nintendo proof of purchase of one of several selected GameCube games, including The Wind Waker, F-Zero GX, Mario Kart: Double Dash!!, 1080° Avalanche, Mario Party 5, and Eternal Darkness: Sanity's Requiem. Consumers could also send proof of purchase of two titles from the Player's Choice range to receive the game
Yes! I got this bonus disc as a pre-order bonus for wind-waker. The "harder" version of Ocarina was a new triple A game all by itself and is still included in the Nintendo virtual console versions of the game on Switch and Gameboy from what I understand.
Wholesale usually requires you buy so many units, and it becomes hard to manage your inventory. Even if this guy couldn't sell half of these, he could return them all to his closest Walmart for only the loss of his travel. Also hot items are usually either exclusives or something you could not be a retailer of. I know there are people that buy things up on Alibaba in bulk then sell them here on Amazon and eBay...the problem is that helps counterfeiters.
