Think the biggest slow down is from it running all the test suites in isolation in separate contexts (think that's the right word). I got frustrated with how slow our frontend tests were one day like 4 years ago and wrote a hacky jest runtime that reused the context unless it detected jest.mock or jest.spy or timer stuff in the file it was on. It speed it up by 2x with cache cleared. It was still pretty slow though...
There was also an existing issue opened requesting this to be built in by a lot of people and facebook said lol no.
Here's a fun fact, most fonts have a font program written in a font specific instruction set that requires a virtual machine to run. There is no escaping the VMs!
A VM is not a VM. Just because a program’s semantics are defined in-terms of “a” virtual-machine (Java, .NET, etc) - it’s otherwise entirely unrelated to virtualisation.
It always kind of cracks me up when I hear someone having to explain the difference between between these 2 breeds of VM.
At one point back in school a friend said to me "hey, I can't figure out how to install and boot JVM on Virtual Box. I need to use it for homework in another class. Help me?"
I wish I had been able to explain it as succinctly as you. Instead I sat there laughing in the guy's face for a good minute, eventually realizing from his expression that he was being serious, which only made me laugh even harder.
This is not trivia. For better or for worse truthy evaluation is a fundamental part of the language which is what this code snippet appears to be primarily testing.
Don't see how you could consider the question they posed to be trivia for someone who knows javascript? Abuse of truthy evaluation is very rampant. All the JS codebases I've worked on are filled with `if (!myArray.length)` and etc. I would be very sad if anyone with a year of JS experience couldn't get this problem.
By trivia, I mean it can be thoroughly explained in a paragraph or two.
Separately, if it's the kind of thing that can be learned in less than a year of experience, it's not helpful for determining whether someone should be hired as a senior engineer.
I'm confused how this would reduce disease progression compared to a much cheaper allo bone marrow transplant then if they are only modifying hematopoietic stem cells since a BMT is just doing the exact same thing except with someone else's non affected cells. BMTs are a horrific procedure though so this definitely has an advantage in that regard.
I would also have to imagine they would have to do myeloablative chemo or radiation to make sure the fixed cells propagate more than the diseased cell line.
Edit: read the study, they do give them the same chemo used for normal transplants.
Most recipients don't need to take immunosuppressants at all if they get PBSC or bone marrow transplants. Even if they do, it's short term. Additionally, the allo grafts need to be matched, which if you're non white is not a good success rate. 85%ish of whites get matched, that number gets depressingly low for minorites. On the US registry, only 1 in 400 donors get called. I happen to be one of those donors and a system where I'm not needed is a better one. The best part is no part.
>Previous studies have shown that 30% to 70% of all patients surviving beyond 100 days after HCT require treatment for chronic GHVD,2,4-6 often for more than 2 years.
Re: a better system is where you don't need donors:
Matching involves the now simple (if costly) task of comparing diplotypes at immune system loci involved in self recognition, like the MHC.
What's horrific to me is that matching by race is still a thing! These genes are under diversifying selection. That means that they often do not match the surrounding genetic background. That means that racially driven matching is bonkers.
I was getting at the article giving the impression this somehow cured the disease vs a BMT just slowing progression. I know the whole transplant thing sucks. I've had two transplants, thank you for being on the list :).
The article indicates they don't know. "it is not yet clear whether it will persist life-long, and extended follow-up is needed" - So they can be optimistic without knowing for sure because they don't have a bunch of kids they treated say ten years ago to check on. It seems like this might stick, they hope it will, they can't know yet.
One of my friends gave his wife a kidney which allowed her to get off dialysis, so yeah, thanks to anybody who is willing to do this for someone they don't even know.
Reading the paper [1], the genetically modified stem cells overexpress the ARSA enzyme. This seems to create a ‘bystander effect’ which increases the total body enzymatic activity above some critical threshold sufficient to arrest the disease process. Myeloid cells associated with neuronal structures are probably critical to this benefit. A standard bone marrow transplant doesn’t reach this threshold, and has demonstrated poor efficacy in early onset disease.
Definitely true GVHD sucks. The article gave me the impression that they were saying it was somehow superior at stopping the disease because it said this "stem cell transplants, have sometimes been used to slow the disorder's progression in infants,"
(fyi a decent amount of stem cell transplant survivors do not have to take immunosuppressants for life)
"Sorry I missed your comment of many months ago. I no longer build software; I now make furniture out of wood. The hours are long, the pay sucks, and there's always the opportunity to remove my finger with a table saw, but nobody asks me if I can add an RSS feed to a DBMS, so there's that :-)"
There was also an existing issue opened requesting this to be built in by a lot of people and facebook said lol no.