I remember seeing in a Popular Electronics Magazine, in the late 60s or early 70s, stating "There will never be a Blue LED". Despite looking I've not found that issue again.
In Tom Beardens book "Excalibur Briefing: Explaining Paranormal Phenomena" on page 166 he states:
"...Briefly, two groups of cells were selected from the same cell culture and one sample placed on each side of a window joining two environmentally shielded rooms. The cell cultures were in quartz containers. One cell culture was used as the initiation sample and was subjected to a deadly mechanism - virus, germ, chemical poison, irradiation, ultraviolet rays, etc. The second cell culture was observed, to ascertain any transmitted effects from the culture sample being killed.
When the window was made of ordinary glass, the second sample remained
alive and healthy. When the window was made of quartz, the second
sample sickened and died with the same symptoms as the primary
sample. The experiments were done in darkness, and over 5,000 were
reported by Kaznacheyev and his colleagues. The onset of induced
complementary sickness and death in the second culture followed a
reasonable time - say two to four hours - behind sickness and death in
the primary culture.
The major transmission difference between window glass and quartz is
that quartz transmits both ultraviolet and infrared well, while glass
is relatively opaque to ultraviolet and infrared. Both quartz and
glass transmit visible light. ..."
Based on this work:
V.P. Kaznacheyev et al, "Distant Intercellular Interactions in a System of Two Tissue Cultures,"
Psychoenergetic Systems, Vol. 1, No. 3, March 1976, pp. 141-142.
I must give some background so you don't think I'm being factious or silly by what I'm about to explain.
Next week it will be twelve years since my wife killed herself due to Chronic Pain. Willing or not thrusting me into being an advocate for those with Chronic Pain. Most specifically advocating for those with Intracranial Hypotension due to Cerebrospinal Fluid (CSF) Leaks and those poisoned by Fluoroquinolone antibiotics such as Levaquin, Cipro etc.
See our documentary Pain Warriors about the whole saga of my late wife. It is free to watch many places. I get no remuneration of any kind from Pain Warriors.
As someone with Lupus "The Spoon Theory" was created by Ms. Christine Miserandino.
Anyone that spends time in Social Media related to chronic health issues is going to come across someone talking about 'Spoons'. Yes, the utensil that you eat with.
A normal health person has an unlimited number of spoons per day. Someone with a chronic condition may only have five or ten if they are lucky.
Each 'Spoon' represents a task of daily life. Say just getting out of bed, taking a shower or eating a meal, each being one spoon.
When you run out of spoons for the day your day is over, or you start paying by borrowing spoons from tomorrow, which makes tomorrow a worse day than today.
So the linguistic words being looked for are already being measured by the community itself in a scale of Spoons. As silly as it might sound.
Ms. Miserandino explains how this all came about here:
Something I need to add, because I mentioned Lupus, is that food sensitivities to Nightshade plants, common in our diets, can mimic the systems of Lupus and Rheumatoid Arthritis. If you or a loved one has those, eliminate the Nightshade family from your diet for a while and see if there is any improvement.
One of the known side effects of this drug is Suicidal Ideation.
My late wife was taking this crap when she killed herself; see the documentary Pain Warriors for that whole saga.
I've been warning people about this drug for years. One lady told me, months after a warning to her group: "Bob, I was standing on the railing of a bridge ready to jump, when I heard your voice. I got off of the bridge and got help."
This stuff really needs to be removed from the market. I acknowledge that I've been told by a very few that it helps them. I've been told by far more how it harmed them.
See also from the Journal Cell Oct 16 2009, relating to both Gabapentin and Lyrica, because other comments here are speculating about how it works:
"... α2δ-1 is the high-affinity receptor for two commonly prescribed antiepileptic, antineuropathic pain medications, gabapentin (GBP, Neurontin) and pregabalin (Lyrica) (Gee et al., 1996). GBP and pregabalin were initially designed as hydrophobic gamma amino butyric acid (GABA) analogs that could cross the blood-brain barrier. Further studies have shown that even though they posses anticonvulsant properties, they do not bind to GABA receptors or transporters. A recent study using a knockin mouse that expresses a mutant α2δ-1 that cannot bind GBP or pregabalin has shown that α2δ-1 is the in vivo target for these drugs and that these drugs mediate their therapeutic action through binding to α2δ-1 (Field et al., 2006). GBP and pregabalin do not affect the single-channel kinetics of calcium channels and have only modest effects on neurotransmission (Dooley et al., 2007). Thus, the cellular mechanisms underlying the mode of action of these drugs are unclear. ..."
All antidepressants cause same, and evidence that they work is not awesome (they work barely better then placebo)
The question is should the whole industry be destroyed, or what?
Very hard things to solve. Opioids help with pain, but destroy lives in the long term. Should they be almost never prescribed, except in severe pain and never longer then a week (except in hospice?)
The smallest capsule of pregabalin/lyrica is 25mg. After reducing to that minimum, it still took months of further tapering by dividing capsules, before withdrawal symptoms ended in one elderly patient. Pregabalin suppresses nausea, which means nausea is a symptom of withdrawal, requiring ginger tablets or other anti-nausea assistance during tapering.
> An investigation by The Sunday Times has revealed that pregabalin has the fastest-rising death toll of any drug in the UK, based on figures compiled from official data across all regions. It is detected in a third of all drug-related deaths. In 2012, pregabalin was indicated in nine fatalities. A decade later, in 2022, the number had risen to 779, with almost 3,400 deaths in the past five years.
Yet sadly it is still on the market. Is there a number of deaths that are enough?
There is also this small 2016 study:
"Interference with neuronal development
Pregnancy outcome following maternal exposure to pregabalin may call for concern
ABSTRACT
Objective: To investigate pregnancy outcomes following maternal use of pregabalin.
Methods: This multicenter, observational prospective cohort study compared pregnancy outcomes in women exposed to pregabalin with those of matched controls (not exposed to any medications known to be teratogenic or to any antiepileptic drugs). Teratology Information Services systematically collected data between 2004 and 2013.
Results: Data were collected from 164 exposed pregnancies and 656 controls. A significantly higher major birth defect rate in the pregabalin group was observed after exclusion of chromosomal aberration syndromes, and when cases with exposure during first trimester of pregnancy were analyzed separately (7/116 [6.0%] vs 12/580 [2.1%]; odds ratio 3.0, 95% confidence interval 1.2–7.9, p = 0.03). The rate of live births was lower in the pregabalin group (71.9% vs 85.2%, p < 0.001), primarily due to a higher rate of both elective (9.8% vs 5.0%, p = 0.02) and medically indicated (5.5% vs 1.8%, p = 0.008) pregnancy terminations. In the Cox proportional cause specific hazards model, pregabalin exposure was not associated with a significantly higher risk of spontaneous abortion.
Conclusions: This study demonstrated a signal for increased risk of major birth defects after first trimester exposure to pregabalin. However, several limitations such as the small sample size, differences across groups in maternal conditions, and concomitant medication exposure exclude definitive conclusions, so these results call for confirmation through independent studies."
In theory, LLMs could review more sources for a personalized risk assessment. But a brief query on this subject yielded generic responses from multiple LLMs :(
I've seen AI recommended things like Fluoroquinolones (Avalox, Cipro, Levaquin etc), for UTIs.
The FDA itself says this class of drugs work no better than a placebo for UTIs, Sinusitis and Bronchitis. While they cause life altering side effects. They 'Flox' people.
My late wife's Journal was part of the evidence during a 2015 FDA hearing to get this crap off the market.
The bottom line is that AI can not be trusted for Medical Advice.
Be highly suspicious of a Human doctor recommending a drug in this class, that has so many Black Box Warnings.
In some Embedded areas where safety is of high concern following the Motor Industry Software Reliability Association (MISRA) guidelines is a requirement.
There may be no heap at all and memory must be pre-allocated at system initialization. Otherwise CXXStateTree sounds like it could be very useful in my Embedded devices, which rarely have enough Flash or RAM space, which is the nature of the work.
At the Pittsburgh airport the guy at the conveyer belt for the luggage scanner told me to leave my shoes on, as he did for the person before me.
When we got to the body scanner the guy there told me to take my shoes off and put them on the luggage belt. Person before me walked right through with their shoes on.
One TSA agent sees me removing my lacrosse ball from my bag. He says “no that can stay in there”. I say no your scanners always stop me because of it. He replies “you will be fine” and I put it through in my luggage. I go through security and sure enough my bag is stopped. After they pull it out, swab it down like it’s contraband, they say I can go I say no, I’d like a supervisor. I ask the supervisor to bring the other agent over that told me it would be ok. Supervisor immediately sees the problem and begins to tell me ways to avoid the security theater including ignoring the agents and removing things that are constantly flagged. It makes both of our lives easier he said. Just made me wonder what the point of all of this was.
In the end he told me avoid lines with multiple TSA agents at a single station since they are in training and will stop almost everything. I smile, thank him for giving away all of their opsec and walk away shaking my head. It’s all a joke.
Pittsburgh barely cares about belts and shoes now. Little Rock is pretty lax too. Honestly, one shoe bomber didn't ever inspire copycats (because it was a dumb plot)
