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It depends if the vaccine is sterilizing (destroys the virus) or leaky (symptoms are prevented but virus is not destroyed).

Leaky vaccines do change evolutionary pressure and increase the likelihood of escape variants.

For a case study in the worst case outcomes of leaky vaccines, see Marek's disease [1].

It seems like the mRNA vaccines are at least partially leaky, so there have been concerns raised and alarms sounded by researchers.

[1] https://en.wikipedia.org/wiki/Marek%27s_disease


If the argument is "we shouldn't use vaccines because of escape variants" then I don't see why we should fear escape variants more than we do any other kind of variants.

If the argument is "we should build up a big inventory of vaccines and infrastructure to deploy them to the population in a very short timespan" then I see some logic to that but it's not at all obvious that the math works out.


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