well, they are. outsourcing is the bigger problem. just like outsourcing decimated manufacturing jobs, now it's decimating white-collar. i well and truly hope you get fired so you see how bad the market is. no other profession has this number of cruel, judgmental narcissists not looking out for their own kin.
There is no but. There are 700x more gun homicides in the US vs the UK, with just 5x the population. You are the only developed country in the world where active shooter response training is a thing. Tools do make it easier, so it should be hard to get them, especially when they are specifically made for no other use than killing people.
This is not a good argument. How many people in Japan die from gun shots in a typical year. Tools are absolutely the problem. With that many craY guns out in the US you are simply significantly increasing chances of shit happening.
dosed reasonably (~125 mg with no redoses), ideally at lower ambient temperatures, and ideally with an SSRI at the end of perceptible effects to stop MDMA to keep circulating through the neuron and causing oxidative stress, you will quite literally see 0 axonal damage. maybe some neurotransmitter depletion, but this is only temporary.
PCA yes that is concerning but I would be extremely surprised if it ended up in the MDMA supply chain. MDMA is made cheaply at quantities several magnitudes higher than research chemicals. it's much more likely PCA will be sold as a cut for others RC's -- especially as a part of those dreadful cathinone soups labelled "3-mmc" these days
There is absolutely no scientific backing to support such an absolute claim.
The animal studies using SSRIs worked because they dosed the SSRIs before the MDMA. By occupying the serotonin transporter the MDMA is prevented from entering the neurons, which prevents the damage.
Taking an SSRI afterward might do something for the very tail end of the dose, but that's after most of the action and therefore most of the damage. You can't get all of the recreational effects, then block the transporter afterward and expect the same protection.
SSRIs are also potentially dangerous with MDMA due to the possibility of serotonin syndrome.
There have been numerous recipes floated around in drug circles for combating the neurotoxicity but they’re extrapolations and hypotheses, not firmly supported concepts.
You should avoid SSRI:s adjacent to MDMA use. The hypothesis is that by blocking the serotonin transporter you'd avoid dopamine getting reabsorbed into serotonin vesicles, but there is very little evidence that this would work and there are obvious risks.
SSRI:s will give you a strong tolerance against serotonergic drugs and it will take a long time to lower that tolerance, months, maybe a year or two. As far as I know it hasn't been studied scientifically but I've seen people get quite uncomfortable experiences from MDMA and 5-HT2a-psychedelics (LSD, psilocybin, mescaline, those) after being off SSRI medication for several months, that I amateurishly attribute in part to downregulation of serotonin sensitivity.
A more acute risk is MAO inhibitors, which are sometimes prescribed as antidepressives. You're more likely to suffer acute damage or die from a combination of MDMA and an MAOI than with an SSRI, though neither is a good idea.
The Bluelight forums are a decent source of harm reduction advice, https://www.bluelight.org/community/forums/. Be aware that some participants in the discussions have problems with risky or abusive use, or give bad advice. Stickied guides tend to be of high quality, however.
2mg/kg dose, so ~160mg for an adult human. More importantly rat to human is usually a 6ish HED factor so that’d be <30mg. In reality metabolism, brain volume, etc all matter but this is not an even remotely safe drug.
Also taking SSRIs near MDMA administration is one of the worst pieces of what is doubtless intended as harm reduction advice I’ve ever seen. You don’t hand people a recipe for serotonin syndrome because of a small scale rat test or two.
> Also taking SSRIs near MDMA administration is one of the worst pieces of what is doubtless intended as harm reduction advice I’ve ever seen. You don’t hand people a recipe for serotonin syndrome because of a small scale rat test or two.
you have a deep understanding of releaser pharmacology if you state this. don't take it from me though--matthew baggott, one of the leading researchers studying enactogen pharmacology recommends doing this exact thing
Okay, I looked at Baggott's work a little more. Here are my primary concerns:
1. He's talking his book to a certain extent. This is his life's work and he runs a company in this space (though a B corp) so he will have a bias here. That's fine overall, as it may help balance people unfairly biased against psychedelics, but it's worth remembering. I'm not saying this to impugn his character so much as to point out everyone has biases, and someone in his position likely has strong ones, even if partially-founded.
2. He believes an SSRI alleviates negative symptoms, but we don't know it does more than alleviate the comedown. It appears his endpoint was cognitive performance post-use, not long-term damage that may appear once off the SSRI.
3. This doesn't touch the dopaminergic risks of amphetamines, which are substantial.
A few exploratory bits of research into one potential way to alleviate the acute effects post-administration don't translate to an established method to use this in a remotely-safe fashion.
it's interesting you bring that up as it turns out the incumbent party was actually the one behind that tiktok campaign, not russia. the campaign they used as evidence of "russian interference" that they cancelled the election because of
It's irrelevant to my point who did what. The elections were still influenced (though it saddens me that people are so easily influenced, but that's orthogonal too).
Is the content on the TV generated for you by some black box algorithm? Is it hard to determine who finances the political ads you see on TV? No and no, so no.
and how is a black box algorithm any worse than a system where only large corporate gatekeepers control what you see? if anything, i'd argue tiktok is more fair and democratic.
terms like "oversocialized" suggest you spend too much time on imageboards and you would do well to get off those sites. same with "humiliation ritual"
> I'm speculating here but I'm pretty sure if you did an MRI on my brain you'd see lesions from the mixing of mdma and sertraline
ssris actually block the serotonergic effects of mdma and similar.