Blender is great, but the UI is very non-standard (for little benefit). A good program can be used by domain experts without reading the manual, something that's not possible with Blender. 3D Max, 4D Studio, and CAD apps like CATIA have a much more intuitive UI.
Yes. I've dabbled with blender a couple of times, and it's infuriating how hard it is to do simple things like rearranging palettes. Blender is different than any other software I've used, and is unique in requiring a tutorial just to understand basic stuff like how to open and save files...
