They didn't work so well for him when he put that final gun in his mouth.
Look, I'm a big HST fan, and the drugs, alcohol, violence and insanity sure led to some great times for his readers. For his family, and in the end for himself--not so much.
Thompson didn't commit suicide in some Kurt Cobain "woe is me" manner. He shot himself at age 67 after battling painful and chronic medical conditions, when he decided he had lived a full life and wanted to go.
I'm not trying to advocate alcohol & drug use, I just thought it was a fun quote and somewhat on-topic. It's supposed to be tongue in cheek, at least that's how I interpret it.
Hunter S. Thompson