The public just basically needs to push grassroots research projects to combat big pharma's countermeasures. That will also be the only way we get any real value from other drugs like MDMA, LSD, etc.

Why? They'd do the same as they do with all, effective but off-patent drugs: produce patented variants (e.g. Modified release, like in this example, or combinations with other drugs) and market the hell out of them.