Wow. I searched for my startup and it immediately came up with a breakout box for "<name> (Startup)" with additional links to our VC, a crunchbase profile, and more. That's actually better than Google in semantic relevance.
I agree this is pretty cool, but the more I search the more I feel that the results are targeted solely towards early adopters. Google is the behemoth that it is because normals mistake it for the very Internet itself. If duck duck go wants a shot at any significant share of the search market they'll have to be more welcoming of those same type of folks.
It's funny, because it's really designed for normals, and the early adopter types complain a lot (rightly so from their perspective) about things for them--bigger text, less density, lighter feel, etc. I do make features for early adopter/advanced users though. It's really a hybrid approach in attempt to "cross the chasm" and get these folks to help introduce it to normals, e.g. their parents and siblings.
Cuil looks pretty bad UI-wise. UI elements are presented in the same style as content text, which makes quick skimming difficult. A one-column layout turns into a two-column layout without any visible logical separation and no warning.
The no-warning column change also confuses the user the third column - which is consistent. I look at that page and my brain hurts.
Compare with Duck Duck Go, where UI elements are immediately obvious, and the text doesn't switch layout/flow on you half way down the page.
Also, DDG doesn't steal a bunch of pixels from your browser window permanently - not sure why this still exists in 2010.
I think more of these types of Internet me-me pictures should appear at the top of the search results(maybe not so huge, but very prevalent). It gives personality to the business that is search. Why use Google when there is a search engine that provides the results you seek but does so with humor.
After the obligatory vanity search yielded positive results (this rarely happens because I'm a nobody), I'm giving it a one week trial as my default search engine.
[Edit]
It seems to be giving way better results than Bing. Nice to see that smart dudes in garages can still give megacorps a run for their money in their own backyards.
For the record, this joke was the idea of Alexis Ohanian (kn0thing) of YC & reddit fame. I want to check with him first before outing him--hence the delay :).