When talking about potential harm of a substance, it is important to qualify the risk. Transient down-regulation of serotonin receptors is not really the same thing as post-relationship breakup blues.
MDMA is famous for inducing temporary depression, ala a "breakup blues". The risk of extended or even permanent depression issues is not well known at this time, it does not seem likely from occasional doses as I understand it. But it still seems to remain a possibility with very high or extended doses. Certainly there's enough anecdotal reports out there that seem to suggest this.
MDMA is famous for inducing temporary depression, ala a "breakup blues". The risk of extended or even permanent depression issues is not well known at this time, it does not seem likely from occasional doses as I understand it. But it still seems to remain a possibility with very high or extended doses. Certainly there's enough anecdotal reports out there that seem to suggest this.