Then reject email addressed to localhost. It shouldn't matter how the email got there. I'd suggest that especially given DNS trickery involving setting up a low TTL then redirecting to 127.0.0.1, you're probably not preventing this from happening or you'd have to invalidate any unrecognised domain. Better to solve that problem at a different layer -- validate the email by sending a validation link if you must...
And their point is, it's a backend issue, the backend being the mail client/server that already completely handling the sending/receiving of emails. Either the activation link gets clicked or it doesn't. The click is the only correct validation, and yes, the whole process happens on the "backend".