What's really needed is a third party JavaScript comment system you can map to your own domain, which means the Comment api would have to be cors enabled, and support custom domains i.e. So you configure the service to serve comments from blog.mysite.com. uBlock surely won't block the same domain.

It really depends on the website. I used to love commenting on Motherboard until they did away with comments. I just recently discovered that AVClub has a pretty tolerable and insightful community at the moment.