It's not impossible, it's a cultural mismatch. Perl is obscenely permissive, which makes it a really interesting and weird language.
But when you work in a big team and make something complex, you want something that's consistent. All of that permissiveness and flexibility bites you.
Now, with good styling guides and linting, you can make it work for complex software with a big team, but that's culturally pretty anti-perl. We're trying to do that with Javascript now, which isn't as weird as perl, but has many of the same excesses that you want to reign in with a style guide.
But when you work in a big team and make something complex, you want something that's consistent. All of that permissiveness and flexibility bites you.
Now, with good styling guides and linting, you can make it work for complex software with a big team, but that's culturally pretty anti-perl. We're trying to do that with Javascript now, which isn't as weird as perl, but has many of the same excesses that you want to reign in with a style guide.