The keyboard shortcuts certainly take some getting used to, and using XQuartz means that it doesn't integrate well into the OS. For instance, Cmd+Tabbing doesn't work when you select the application itself; you have to select the XQuartz instance.

The fact that most of Inkscape's controls are bound to function keys, and that function keys require a modifier by default on macOS doesn't help either.

Still... I greatly prefer Inkscape to Illustrator for the type of work I tend to do in it (creating vectors for a vinyl cutter).