Nope, but I run it at 100% scaling. I did notice that if the source on the TV is not labeled "PC" then the Mac uses YCbCr 4:2:0 and looks like garbage. Setting the input label to PC must send a different EDID because it seems to use RGB... On my Windows machine I can just override that in the nvidia control panel.
Are you driving this from a Mac or from a PC? What kind of cable are you using exactly?