It certainly would... as long as you're hosting the comment backend somewhere -- which might defeat the purpose of going with a static site generator in the first place (if your purpose was to only host static files).
This is exactly the issue I encountered. I run a pelican static blog on github. I just host my comments as a simple flask app on www.pythonanywhere.com Code here: https://github.com/singhjaideep/flask_comment
