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The poles will see the largest destabilization due to several effects, a major one being the loss of the Walker circulation cell (which causes El Nino).

In order for the south pole to be the best place to live all the ice would have to melt, which would essentially end life on earth as we know it. The sea level would rise about 100m, which would kill so much life on land that it would make the atmosphere unbreathable and kill everything else.

More fundamentally if we can't get it together enough to stop this, I find it highly unlikely we'll be able to put together a self-sustaining shelter on what will basically become an alien planet. We'd have to survive indoors for the length of our written history, minimum. It's not so much that it's outright impossible, but any tiny problem could lead to our extinction over ten thousand years. It's a lottery ticket for our species, and the only realistic expectation is that we will lose.

Plus there are tons of survival-killers that just get discounted. Will we be able to keep ourselves going technologically without a global distribution of resources? Will our genetic diversity survive isolation? Will we be able to survive antibiotic-resistant diseases?

We're struggling to stay ahead of antibiotic resistance with decades of mutation- once we no longer have the scientific effort to devote to controlling this, will we be able to do anything about centuries or millenia of bacterial evolution? A freak drift or reservoir incident (eg ebola in bats) could wipe us out in a week or two.



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