Why on earth would you trust substances humans have been using for thousands of years in favor of something brewed in a lab by a pharma company with quarterly goals and a decade (or two?) of tests (perhaps with incomplete test coverage). Difficult choice.
Adderall (a drug with extensive safety research conflict of interest, thus bias). I caught a guest (friend of a friend) snorting Adderall & she looked/acted like a meth addict.