I'd strongly suggest using Webpack to build any new serious frontend projects. It's incredibly powerful and flexible enough to be able to adapt to any changes in the ecosystem without having to throw stuff away. As a data point, I know a large projects that slowly migrated away from AMD, favoring CommonJS, and later ES modules. Since ES modules are part of the standard, it makes sense to converge. This was achieved with comparably minimal effort, without throwing code away, and all while enabling newer code to be written in the modern style.
React is an incredibly safe bet as well. Facebook is so heavily invested in it that they have multiple engineers working on it full-time. Furthermore, since they actually use the framework, any breaking changes are required to have a clear migration path. They published a blog post [0] explaining their strategy for how they intend to handle version transitions, which I consider incredibly developer-friendly. Look at angular 1.x for an example of a horribly handled transition.
React is an incredibly safe bet as well. Facebook is so heavily invested in it that they have multiple engineers working on it full-time. Furthermore, since they actually use the framework, any breaking changes are required to have a clear migration path. They published a blog post [0] explaining their strategy for how they intend to handle version transitions, which I consider incredibly developer-friendly. Look at angular 1.x for an example of a horribly handled transition.
[0] https://facebook.github.io/react/blog/2016/02/19/new-version...