Out of five vehicles built, two have been lost. I think you can find sources on those two incidents easily enough.

According to wikipedia, there were 135 shuttle missions. So, a 1.481% failure rate in case anyone was wondering.

From a commercial, ROI standpoint, having %40 of your hardware eventually destroy itself is bad news. Especially since each time your whole enterprise stops for years until you find out what went wrong and fix it.

What?! All hardware failes eventually. If you get an average of 27 of flights from a single rocket, I'd say that's outstandingly good news!

Nobody is arguing that hardware doesn't eventually fail so I don't know why you mention that.

False. It's not outstandingly good news, not if we want to become multi-planetary in short order. We need to get to better than commercial airliner standards quickly.