Keep zooming out and we're all little hypertriangles in some N-dimensional cellular automaton, and there's no such thing as 'meaning', just patterns of higher or lower entropy. Don't think too much about it or it'll just make you depressed.
Bit of a late reply, sorry, but I didn't mean that nihilism was the answer. I just meant that humans aren't well equipped, emotionally, to deal with the universe at scales too different from those at which we evolved.
You just can't afford to 'zoom out' too far. Focus on immediate small scale things, watch a beautiful sunset, hug your kids, ride a motorbike, eat your favourite meal. Focus on near-term goals like "bootstrap my company" or "reach my fitness goals". Worry about little problems that you can solve. Make someone smile. Smell the roses.
You can stay intellectually aware of the fact that we're transient pond scum on the surface of a space rock in an infinite, arbitrary universe. Just don't dwell on it.