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It can be done with essentially a recompile as long as it's all digital, but the result won't be great. If you want to use area well, get high clock rates and power efficiency, you really need to spend a significant amount of effort on physical design.

Technically speaking, you have to worry about these things on FPGAs as well.

But FPGAs and ASICs are quite different, so you'll have to adjust the design for those differences. In fact, you may have to adjust the design when switching fabs, because of process differences and resulting standard cell library differences.




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