Block all accesses to non-local (192.168, 10., etc) IP-based URLs. Will break some legit stuff, but, not that much for most users, and they can just whitelist that as it comes up.
IP whitelists could also be aggregated and shared on github similar to the current DNS blacklists.
If you're using uBlock Origin or uMatrix to block third party scripts it won't matter. That's what makes using the dynamic filtering in uBlock Origin so powerful. Easily the best bang for your buck ad blocking that you can do.