>"Nobody understand the brain well enough to do that yet."
I'm fairly certain I understand the brain well enough to know our understanding of the brain is rudimentary and there is no reason to become attached to a vague preliminary model like this "amyloid hypothesis".
It's not so vague as it might sound. There's good evidence that people with amyloid plaque build-up, in the brain or in other organs, have different versions of the genes that code for the production of amyloid proteins than people who do not.
I'm fairly certain I understand the brain well enough to know our understanding of the brain is rudimentary and there is no reason to become attached to a vague preliminary model like this "amyloid hypothesis".