Somebody mentioned The Sirens of Titan (Vonnegut) in the comments below. I've gotta second that recommendation. It's Vonnegut's first novel, and probably not his best, but it's certainly my favorite.

If you resonate at all with Vonnegut's humor and pathos, then please oh please grab a copy of Sirens. I'm tired of being the only one at the dinner table who's read it!