Depends on the hardware and the anti-tamper measures. I've seen POS terminals where the pcb was completely encased in security plastic, where any attempted breach would wipe the internal security keys, which meant the hardware just became a useless. They're so sensitive that these things enter "tampered state" from time to time without any tampering. I developed software on these things - and bricked multiple devices by accident, even though this was 'development' hardware.

I have caused production outage during one of our reviews of the rack with the HSM. The procedure required opening the rack, inspecting and accounting for all devices and cables and then checking the status of the HSM itself. At the end of the procedure the rack had to be closed.

Visa/Mastercard required that there are two people present and that there are two people required to open the rack.

We had it modified so that it has second lock.

The additional lock did not fit perfectly. During the procedure when I tried to close the door the door snagged on the lock and then slammed shut. It wasn't a lot of force but it caused the HSM to loose its keys and required a lengthy procedure to get three security officers to initialize the HSM with components stored on their smart cards during which the whole system was unavailable.