SharePoint Online’s user interface has been rewritten in recent years using an open source stack (node.js, React etc) and certainly works far better using Chrome and not IE. This is true of SharePoint on-prem too, at least the recent versions. Even the tools we use to make web parts now are React, Yeoman, webpack, Yarn, Sass etc. Microsoft are heavily investing in these and most of the training materials they produce for developers are pushing us more and more in that direction.