How many of these drugs actually do work in mice? Every study that comes out on the topic shows at least 50% and often closer to 90% of preclinical research does not replicate or even is not replicable in principle.
Research and drug development are pretty different leagues. A research paper might be 3 researchers with 20 mice. When your looking at preclinical trials it’s more like 300 people and 5000 mice per trial and god knows how many trials before something goes through.
The reproducibility crisis is happening in academia. There isn’t that much room for uncertainty when it comes to industrial drug development. You won’t find drugs making it all the way to market only for “another group” to be incapable of reproducing the effect.
> "When your looking at preclinical trials it’s more like 300 people and 5000 mice per trial and god knows how many trials before something goes through."
This is sampling to a foregone conclusion. It is guaranteed to yield unreproducible effects.
> "You won’t find drugs making it all the way to market only for “another group” to be incapable of reproducing the effect."
