One major change in 2.8 is that it defaults to left-click for selection. At least from my experience, right-click selection was the big thing that made Blender feel very alien to pick up.

You could change it before, but defaults matter a lot for new users.

EDIT: I just tested it and I might be misinformed on this. Either it's still RMB selection or I have an old config that it loaded.

EDIT2: Load factory settings put me on LBM select. Yay!