With default theming, GTK+2 looks like a bad ripoff of Windows 9x. (It's quite ugly, but not quite as bad as FLTK) GTK+3 has much better default theming.
Unfortunately there's still a lot of legacy apps out there, and others where the dev unfortunately picked GTK2 despite 3 being available. Not to mention some GTK3 apps not including the proper themes
GTK still has extreme padding and wasted screen real estate around texts, images, lists and other component. Making a slim version and better designed UIs would probably make a lot of difference.
On you typical laptop 14" FHD display, exactly this padding and sizing looks great (at @1x), while at 14" 1600x900 it still looks very good. Sure, on 1376x768 it looks terrible.