(Full disclosure, i run a YC startup selling to synbio + think that it's undervalued)
The field really doesn't do blog posts, it's a shame.
For some interesting stuff in synbio that's approachable to your prototypical HNer, check out [1], a Verilog-to-DNA compiler that works with small logic circuits. [2] (Not really synbio) but using reed solomon codes to better do High-Throughput Screening. [3] PACE, a way to ask evolution to implement a particle filter for us. [4] A remapping of the base pair 3-tuple to amino acid that maximizes edit distance, filling in the gaps with STOP codons - stopping something from evolving, and [5] some cool people working on wholly synthetic cells.
[1] Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., … Voigt, C. A. (2016). Genetic circuit design automation. Science, 352(6281). https://doi.org/10.1126/science.aac7341
[2] Erlich, Y., Gilbert, A., Ngo, H., Rudra, A., Thierry-Mieg, N., Wootters, M., … Zuk, O. (2015). Biological screens from linear codes: theory and tools. BioRxiv, I(1), 35352.
[3] Dickinson, B. C., Leconte, A. M., Allen, B., Esvelt, K. M., & Liu, D. R. (2013). Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proceedings of the National Academy of Sciences, 110(22), 9007–9012.
https://doi.org/10.1073/pnas.1220670110
Esvelt, K. M., Carlson, J. C., & Liu, D. R. (2011). A system for the continuous directed evolution of biomolecules. Nature, 472(7344), 499–503. https://doi.org/10.1038/nature09929
The field really doesn't do blog posts, it's a shame.
For some interesting stuff in synbio that's approachable to your prototypical HNer, check out [1], a Verilog-to-DNA compiler that works with small logic circuits. [2] (Not really synbio) but using reed solomon codes to better do High-Throughput Screening. [3] PACE, a way to ask evolution to implement a particle filter for us. [4] A remapping of the base pair 3-tuple to amino acid that maximizes edit distance, filling in the gaps with STOP codons - stopping something from evolving, and [5] some cool people working on wholly synthetic cells.
[1] Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., … Voigt, C. A. (2016). Genetic circuit design automation. Science, 352(6281). https://doi.org/10.1126/science.aac7341
[2] Erlich, Y., Gilbert, A., Ngo, H., Rudra, A., Thierry-Mieg, N., Wootters, M., … Zuk, O. (2015). Biological screens from linear codes: theory and tools. BioRxiv, I(1), 35352.
[3] Dickinson, B. C., Leconte, A. M., Allen, B., Esvelt, K. M., & Liu, D. R. (2013). Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proceedings of the National Academy of Sciences, 110(22), 9007–9012. https://doi.org/10.1073/pnas.1220670110
Esvelt, K. M., Carlson, J. C., & Liu, D. R. (2011). A system for the continuous directed evolution of biomolecules. Nature, 472(7344), 499–503. https://doi.org/10.1038/nature09929
[4] https://www.biorxiv.org/content/10.1101/695569v2
[5] http://buildacell.io/