Oftentimes, multiple failures cascade. About 2 decades back at Ohio State University, there was some renovation work going on. Due to this some sensors were switched off. This was wintertime and heating was on. During a weekend something failed and temperatures in a few rooms went as high as 50C. These rooms were used to house mice and rats for several long running experiments and all of them died or had to be euthanized as the data was unusable. Some people lost years of work.