The corollary, which I deal with a lot, is that allergies such as MCAS and other mast cell issues cause tongue edema with the same effect. Antihistamines (H1 and H2 blockers) can help in the short term but have severe drawbacks, such as interfering with melanin formation. Ginger and many antidepressants, such as elavil, are also extremely potent antihistamines.