All I will say is that our latency getting a business entity in or out of a SQLite database (running on top of NVMe flash) is on the order of tens to hundreds of microseconds. There will never be a hosted/cloud offering that can even remotely approach this without installing some "bring the cloud to you" appliance in your datacenter.
That said, it's not a fair comparison and I wouldn't want to run a big service on a single sqlite/nvme setup for more reasons than are worth mentioning, but not prematurely optimizing can take you really far - scale and money - with good design.
