In .NET standard (i.e. not .NET Core) you can load and unload assemblies without tearing down whole processes by creating AppDomains within a process. You then load your desired assemblies into these app domain(s), consume and when you need to load say a newer DLL version you just tear down the AppDomain and create a new one for the new DLL's.

It's a feature that's been around since .NET 1.1 and I used to use heavily 10+ years ago.

https://docs.microsoft.com/en-us/dotnet/api/system.appdomain...