The real challenge would be to design a multi-lingual website for both vertical and horizontal scripts. I suspect you'd end up with two very different designs.

It's interesting to look at the Mongolian president's web page (https://president.mn/mng/): It scrolls horizontally. And see how it responds to the hamburger menu, for example.

Edit: Oh wait, the president's web page is itself a good example: Here is the English version (https://president.mn/en/).