>The core claim he makes "all mice are broken" is a hyperbole that a lot of people will tell you is unsubstantiated. He makes it sound like all tests done on mice are flawed because of it.
It isn't hyperbole, if Bret's claims are substantiated. The claims being that most lab mice are from the Jackson lab, that all of their mice have extremely long telomeres compared to wild mice, and that this could have serious implications on the potential harm to humans by some drugs - even while also accounting for the fact that mice are already not a good model of humans and that the same drugs are later tested on humans. (I could elaborate on this, but it's covered thoroughly in the paper and podcast.)
I agree Eric hasn't satisfactorily proved they didn't change the protocols, but if it is the case that all of their mice still have long telomeres, and if all of the other claims are true (most US researchers still using those mice + the other claims), then the claims "most mice used by US researchers are broken" and "most tests done on mice by US researchers are flawed because of it" are likely also true.
I have no idea if the above claims are true, of course, but they should be investigated on their merits.
It isn't hyperbole, if Bret's claims are substantiated. The claims being that most lab mice are from the Jackson lab, that all of their mice have extremely long telomeres compared to wild mice, and that this could have serious implications on the potential harm to humans by some drugs - even while also accounting for the fact that mice are already not a good model of humans and that the same drugs are later tested on humans. (I could elaborate on this, but it's covered thoroughly in the paper and podcast.)
I agree Eric hasn't satisfactorily proved they didn't change the protocols, but if it is the case that all of their mice still have long telomeres, and if all of the other claims are true (most US researchers still using those mice + the other claims), then the claims "most mice used by US researchers are broken" and "most tests done on mice by US researchers are flawed because of it" are likely also true.
I have no idea if the above claims are true, of course, but they should be investigated on their merits.
Bret Weinstein's 2002 paper: https://www.ncbi.nlm.nih.gov/pubmed/11909679
The podcast between Eric and Bret Weinstein covering the full story: https://www.youtube.com/watch?v=JLb5hZLw44s
Not sure if you already listened to the podcast, but if you haven't, I'd recommend listening to all of it.