I’ve had good luck. The biggest hiccup was that you need to pay extra for a public IP.

Super Meat Boy is about as twitchy as I get, and the latency for that is fine (at least in the SF bay area).

Obviously, the GPU can do more than that, but I haven’t tried pushing in that direction.

You'd want to install Parsec on the server, then controllers work automatically (generally). It works pretty well (though I had to stop using Paperspace because I couldn't afford the cost).