Well its really only from an advertising perspective, the advertiser and the network. From the end users perspective they get the choice, if they really want targeted ads they can always turn the third party cookies on.
Target the ad based on the site the user is visiting, not on trying to violate the user's privacy. On a site to do with cars, show car ads. On a site to do with Dell, show Dell ads.
It's not frickin' rocket surgery.
If no one has a site relevant to your ads, there's your hint that no one wants your service/product. If you believe that I'm wrong... start one. Make a site relevant to that interest, and then you can on-sell your product. Build/find the community that believes in the same stuff you do, and engage them.
