You cannot bring cherries into california from almost all USA states (except AZ, NV, CO, and WY). I experienced this personally. The state border crossing took cherries from us while we crossed from Oregon, less than 3 months ago, and dumped the cherries in trash.
This is not limited to businesses, and is not a pandemic measure. This has been a long standing policy, meant to protect california's agriculture. Oh, the free trade exponent country has protectionism practiced by its states.
Yes, I can google. I was hoping you would extend the courtesy of explaining what restriction you meant.
Intuitively, someone transports grapefruits across state lines. Did you mean you personally (i.e. average citizens), as opposed to a business with a permit? Or that grapefruits generally cannot legally go across state lines? I don't know of any inspections of cars for grapefruit except the well-known checks at the California border. Did you mean just CA and their ag inspections or something more general?
This link [1] (dated 2017) mentions a quarantine. Is there a citrus pandemic in effect? (The link it gives is dead.) That would be good context to have.
That link also mentions that you can do it, but need a federal certificate. Is that hurdle what you mean?
I could go on, but the point is: all of that could have been cleared up by just saying what was in your head with that remark, rather than replying only to give a Google results link.
Part of being a helpful participant on a forum is being clear on what you mean rather than expecting everyone else to read several Google results and guess.