Your post reminded me of the presentation on cantor.dust:
https://sites.google.com/site/xxcantorxdustxx/
https://www.youtube.com/watch?v=4bM3Gut1hIk - Christopher Domas The future of RE Dynamic Binary Visualization
(very interesting presentation)
Looks like there's even been a recently open sourced plugin for Ghidra released by Battelle:
