I don't dock points for layout issues (unless they say they have experience in front-end work...), but spelling and grammar is exactly what you should be getting right in an resume. I don't meant to say I would be unreasonable pedant about the use of prepositions, and I'd probably overlook an MS Office autocorrect (like how Excel always changes "HSA" to "HAS", grrr) - and small mistakes must never invalidate someone immediately - but it means I'm going to be in the session with a dim view of the candidate until and unless they demonstrate otherwise.

That said, recruiters and agencies do edit resumes - so if something seems off with a resume (e.g. "20 years experience with Rust") then I do have a policy of directly contacting the candidate with the resume attached and asking them to verify that this is the resume they wrote. It's also why I sign my own resume PDF with my AATL certificate and mention that fact when I get to contact the hiring manager (e.g. "oh hey, did you have a chance review my signed resume? if it wasn't a signed PDF please let me know, thanks!)